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Test Code STFR1 sTfR (Soluble Transferrin Receptor), Serum


Ordering Guidance


This test should not be used for routine iron status evaluation for patients without confounding pathologies (such as inflammation, infection, chronic disease, or malignancy). For such cases order FERR1 / Ferritin, Serum.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL Serum

Collection Instructions:

1. Within 2 hours of collection, centrifuge the specimen.

2. For red-top tubes, aliquot serum into a plastic vial prior to sending.


Secondary ID

623578

Useful For

Aiding in the diagnosis of iron deficiency anemia in patients with chronic disease

Method Name

Chemiluminescent Immunoassay

Reporting Name

Soluble Transferrin Receptor (sTfR)

Specimen Type

Serum

Specimen Minimum Volume

Serum: 0.6 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 7 days
  Frozen  90 days
  Ambient  7 days

Reject Due To

Gross hemolysis Reject

Reference Values

0.63-2.64 mg/L

 

It is reported that African Americans may have slightly higher values.

Cautions

The soluble transferrin receptor (sTfR) immunoassay should not be used for the routine clinical evaluation of patients for iron status when ferritin immunoassay (FERR1 / Ferritin, Serum) would be appropriate, such as in the absence of confounding pathologies (inflammation, infection, chronic disease, or malignancy).

 

Soluble transferrin receptor assays are not standardized, therefore results from different assays should not be used interchangeably.(3)

 

Patients with hemolysis and recent blood loss may have falsely elevated sTfR concentrations.

 

Race-based differences in sTfR have been observed with Black subjects having 9% higher values compared to non-Black subjects.(4)

 

Altitude-based differences in sTfR have been observed with subjects residing at high altitude having concentrations 9% higher than those nearer to sea level.(4)

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

84238

LOINC Code Information

Test ID Test Order Name Order LOINC Value
STFR1 Soluble Transferrin Receptor (sTfR) 30248-9

 

Result ID Test Result Name Result LOINC Value
STFR1 Soluble Transferrin Receptor (sTfR) 30248-9

NY State Approved

Yes