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HelpTest Code PENTS Pentobarbital, Serum
Reporting Name
Pentobarbital, SUseful For
Monitoring of pentobarbital therapy treatment
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Serum RedSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1.5 mL
Collection Instructions:
1. Draw blood immediately before the next scheduled dose.
2. Within 2 hours of collection centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.6 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days |
| Ambient | 28 days | |
| Frozen | 28 days |
Reference Values
Therapeutic range
Hypnotic: 1.0-5.0 mcg/mL
Therapeutic coma: 20-50 mcg/mL
Reducing intracranial pressure: 30-40 mcg/mL
This degree of sedation requires artificial respiratory support.
Toxic concentration: >10 mcg/mL
Cutoff concentrations by gas chromatography mass spectrometry:
Pentobarbital: 0.5 ng/mL
Day(s) Performed
Thursday
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80299
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PENTS | Pentobarbital, S | 3924-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8239 | Pentobarbital, S | 3924-8 |
Report Available
3 to 9 daysReject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
NY State Approved
YesMethod Name
Gas Chromatography Mass Spectrometry (GC-MS)
Cautions
The concentration at which toxicity occurs varies and results should be interpreted in light of clinical situation.
Specimens collected in serum gel tubes are not acceptable because the drug can absorb on the gel and lead to falsely decreased concentrations.
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.