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HelpTest Code LAB3438 Beta-CrossLaps, Serum
Reporting Name
Beta-CrossLaps (B-CTx), SUseful For
Monitoring antiresorptive therapies (eg, bisphosphonates and hormone replacement therapy) in postmenopausal women treated for osteoporosis and individuals diagnosed with osteopenia
An adjunct in the diagnosis of medical conditions associated with increased bone turnover
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumSpecimen Required
Patient Preparation:
Fasting: 12 hours, required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Collect specimen prior to 10 a.m.
2. Centrifuge and aliquot serum into plastic vial.
Specimen Minimum Volume
0.75 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Frozen (preferred) | 90 days |
| Refrigerated | 72 hours |
Reference Values
Males
<5 years: 242-1292 pg/mL
5-9 years: 351-1532 pg/mL
10-15 years: 447-2457 pg/mL
16-17 years: 478-1666 pg/mL
18-29 years: 238-1019 pg/mL
30-39 years: 225-936 pg/mL
40-49 years: 182-801 pg/mL
50-59 years: 161-737 pg/mL
60-69 years: 132-752 pg/mL
≥70 years: 118-776 pg/mL
Females
<5 years: 347-1508 pg/mL
5-9 years: 383-1556 pg/mL
10-15 years: 311-1776 pg/mL
16-17 years: 146-1266 pg/mL
18-29 years: 148-967 pg/mL
30-39 years: 150-635 pg/mL
40-49 years: 131-670 pg/mL
50-59 years: 183-1060 pg/mL
60-69 years: 171-970 pg/mL
≥70 years: 152-858 pg/mL
Premenopausal: 136-689 pg/mL
Postmenopausal: 177-1015 pg/mL
Day(s) Performed
Monday through Saturday
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
82523
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CTX | Beta-CrossLaps (B-CTx), S | 41171-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| CTX | Beta-CrossLaps (B-CTx), S | 41171-0 |
Cautions
Reduced kidney function may lead to reduced urinary excretion of beta-C-terminal telopeptide (CTx) and a consequent increase in the apparent serum beta-CTx concentration.
In rare cases, some individuals can develop antibodies to mouse or other animal antibodies (often referred to as human anti-mouse antibodies [HAMA] or heterophile antibodies), which may cause interference in some immunoassays. The presence of antibodies to streptavidin or ruthenium can rarely occur and may interfere in this assay. Caution should be used in interpretation of results, and the laboratory should be alerted if the result does not correlate with the clinical presentation.
Serum biotin concentrations up to 1200 ng/mL do not interfere with this assay. Concentrations up to 1200 ng/mL may be present in specimens collected from patients taking extremely high doses of biotin up to 300 mg per day. In a study among 54 healthy volunteers, supplementation with 20 mg/day biotin resulted in a maximum serum biotin concentration of 355 ng/mL 1-hour postdose.
Report Available
1 to 3 daysReject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | Reject |
NY State Approved
YesMethod Name
Electrochemiluminescence Immunoassay (ECLIA)
Secondary ID
83175Forms
If not ordering electronically, complete, print, and send a General Request (T239) with the specimen.