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HelpTest Code LAB3406 Diabetes Mellitus Type 1 Evaluation, Serum
Secondary ID
48400Useful For
Distinguishing type 1 from type 2 diabetes mellitus
Identifying individuals at risk of type 1 diabetes (including high-risk relatives of patients with diabetes)
Predicting future insulin requirement treatment in patients with adult-onset diabetes
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| DMEI | Diabetes Interpretation, S | No | Yes |
| GD65S | GAD65 Ab Assay, S | Yes | Yes |
| INAB | Insulin Abs, S | Yes | Yes |
| IA2 | IA-2 Ab, S | Yes | Yes |
| EZNT8 | ZnT8 Ab, S | Yes | Yes |
Method Name
GD65S, INAB, IA2: Radioimmunoassay (RIA)
EZNT8: Enzyme-Linked Immunosorbent Assay (ELISA)
DMEI: Interpretive Comments
Reporting Name
Diabetes Mellitus Type 1 EvaluationSpecimen Type
SerumSpecimen Required
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 4 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 28 days |
| Frozen | 28 days | |
| Ambient | 72 hours |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Reference Values
GLUTAMIC ACID DECARBOXYLASE (GAD65) ANTIBODY
≤0.02 nmol/L
Reference values apply to all ages.
INSULIN ANTIBODIES
≤0.02 nmol/L
Reference values apply to all ages.
ISLET ANTIGEN 2 (IA-2) ANTIBODY
≤0.02 nmol/L
Reference values apply to all ages.
ZINC TRANSPORTER 8 (ZnT8) ANTIBODY
< 15.0 U/mL
Reference values apply to all ages.
Cautions
Negative results do not exclude the diagnosis of or future risk for type 1 diabetes mellitus. The risk of developing type 1 diabetes may be stratified further by testing for human leukocyte antigen genetic markers. Careful monitoring of hyperglycemia is the mainstay for determining the requirement for insulin therapy.
Day(s) Performed
GAD65 antibody: Monday through Friday
Insulin antibodies: Monday, Wednesday, Friday
IA-2 antibody, Zinc Transporter 8 Antibody: Tuesday, Thursday
Report Available
7 to 10 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
See Individual Test IDsCPT Code Information
86337
86341 x3
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| DBS1 | Diabetes Mellitus Type 1 Evaluation | 104673-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 81596 | GAD65 Ab Assay, S | 30347-9 |
| 89588 | IA-2 Ab, S | 81155-4 |
| 8666 | Insulin Abs, S | 60463-7 |
| 34268 | Diabetes Interpretation, S | 69048-7 |
| 64926 | ZnT8 Ab, S | 76651-9 |