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Test Code LAB3321 Procollagen I Intact N-Terminal, Serum

Reporting Name

Procollagen I Intact N-Terminal, S

Useful For

Aiding in monitoring antiresorptive and anabolic therapy in patients with osteoporosis

 

An adjunct in the assessment of conditions associated with increased bone turnover, such as Paget disease

 

This test should not be used as a screening test for osteoporosis in the general population.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Ordering Guidance


This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. A recommended time period before collection cannot be provided, as it depends on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held and assayed after the radioactivity has sufficiently decayed. This will result in a test delay.



Specimen Required


Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 180 days
  Ambient  7 days
  Refrigerated  7 days

Reference Values

Adult male: 22-87 mcg/L

Adult female premenopausal: 19-83 mcg/L

Adult female postmenopausal: 16-96 mcg/L

Reference values have not been established for patients who are younger than 18 years of age.

Day(s) Performed

Tuesday, Thursday

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

83519

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PINP Procollagen I Intact N-Terminal, S 47255-5

 

Result ID Test Result Name Result LOINC Value
61695 Procollagen I Intact N-Terminal, S 47255-5

Cautions

There is diurnal variation of procollagen I intact N-terminal propeptide (PINP) levels, with the values being higher at night. When serial measurements of PINP are performed, specimens should be collected at the same time of the day.

 

PINP is metabolized in the liver. In individuals with severe liver disease, clearance from the circulation might be affected resulting in elevated PINP levels.

 

In rare cases, some individuals can develop antibodies to mouse or other animal antibodies (often referred to as human anti-mouse antibodies [HAMA] or heterophile antibodies), which may cause interference in some immunoassays. Caution should be used in interpretation of results, and the laboratory should be alerted if the result does not correlate with the clinical presentation.

Report Available

2 to 6 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

NY State Approved

Yes

Secondary ID

61695

Method Name

Radioimmunoassay (RIA)