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HelpTest Code LAB2333 Sex Hormone-Binding Globulin, Serum
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Secondary ID
608102Useful For
Diagnosis and follow-up of women with signs or symptoms of androgen excess (eg, polycystic ovarian syndrome and idiopathic hirsutism)
An adjunct in monitoring sex-steroid and antiandrogen therapy
An adjunct in the diagnosis of disorders of puberty
An adjunct in the diagnosis and follow-up of anorexia nervosa
An adjunct in the diagnosis of thyrotoxicosis (tissue marker of thyroid hormone excess)
A possible adjunct in diagnosis and follow-up of insulin resistance and cardiovascular and type 2 diabetes risk assessment, particularly in women
Method Name
Immunoenzymatic Assay
Reporting Name
Sex Hormone-Binding Globulin, SSpecimen Type
SerumSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 14 days |
| Frozen | 90 days | |
| Ambient | 7 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
CHILDREN:
Males
|
Tanner Stages |
Mean Age |
Reference Interval (nmol/L) |
|
Stage I |
10.4 |
17-135 |
|
Stage II |
11.1 |
21-114 |
|
Stage III |
12.7 |
12-138 |
|
Stage IV |
14.5 |
7.7-67 |
|
Stage V |
14.2 |
3.9-40 |
Females
|
Tanner Stages |
Mean Age |
Reference Interval (nmol/L) |
|
Stage I |
10.5 |
16-182 |
|
Stage II |
10.9 |
24-121 |
|
Stage III |
12.5 |
18-87 |
|
Stage IV |
14 |
7.7-108 |
|
Stage V |
14.9 |
10-79 |
ADULTS:
Males
≥18 years: 13.3-89.5 nmol/L
Females
18-46 years: 18.2-135.5 nmol/L
47-91 years: post-menopausal: 16.8-125.2 nmol/L
Reference values for pregnant women have not been established.
Cautions
In rare cases, some individuals can develop antibodies to mouse or other animal antibodies (often referred to as human anti-mouse antibodies [HAMA] or heterophile antibodies), which may cause interference in some immunoassays. Caution should be used in interpretation of results, and the laboratory should be alerted if the result does not correlate with the clinical presentation.
For patients presenting with cirrhosis or subclinical thyroid conditions, carefully evaluate results as these conditions can potentially cause erroneous sex hormone-binding globulin results.
Sex hormone-binding globulin results should be interpreted considering the total clinical presentation of the patient, including symptoms, clinical history, data from additional tests, and other appropriate information.
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
84270
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| SHBG1 | Sex Hormone-Binding Globulin, S | 13967-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| SHBG1 | Sex Hormone-Binding Globulin, S | 13967-5 |
NY State Approved
YesDay(s) Performed
Monday through Saturday
Report Available
1 to 3 daysForms
If not ordering electronically, complete, print, and send General Test Request (T239) with the specimen.