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Test Code LAB208 West Nile Virus Antibody, IgG and IgM, Spinal Fluid

Useful For

Aiding in diagnosis of central nervous system infection with West Nile virus

Profile Information

Test ID Reporting Name Available Separately Always Performed
WNGC West Nile Virus Ab, IgG, CSF No Yes
WNMC West Nile Virus Ab, IgM, CSF No Yes
WNVCI West Nile CSF Interpretation No Yes

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

West Nile Virus Ab, IgG and IgM,CSF

Specimen Type

CSF


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Sterile vial

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Submit specimen from collection vial 2, 3, or 4


Specimen Minimum Volume

0.8 mL

Specimen Stability Information

Specimen Type Temperature Time
CSF Refrigerated (preferred) 7 days
  Frozen  30 days

Reject Due To

Gross hemolysis Reject

Reference Values

IgG: Negative

IgM: Negative

 

Reference values apply to all ages.

Cautions

Test results should be used in conjunction with clinical evaluation, exposure history, and other available diagnostic procedures.

 

The significance of negative test results in immunosuppressed patients is uncertain.

 

False-negative results due to competition by high levels of IgG, while theoretically possible, have not been observed.

 

False-positive results may occur in patients infected with other flaviviruses, including dengue virus, St. Louis virus, and Zika virus and in persons previously infected with West Nile virus (WNV).

 

Because closely related arboviruses exhibit serologic cross-reactivity, it sometimes may be epidemiologically important to attempt to pinpoint the infecting virus by conducting plaque reduction neutralization tests using an appropriate battery of closely related viruses. Such testing is available through the Centers for Disease Control and Prevention and select public health laboratories.

 

WNV antibody results for spinal fluid (CSF) should be interpreted with caution. Complicating factors include low antibody levels found in CSF, passive transfer of antibody from blood, and contamination via a traumatic lumbar puncture.

Day(s) Performed

Monday, Wednesday, Friday

Report Available

Same day/1 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

86789

86788

LOINC Code Information

Test ID Test Order Name Order LOINC Value
WNC West Nile Virus Ab, IgG and IgM,CSF 94853-9

 

Result ID Test Result Name Result LOINC Value
WNGC West Nile Virus Ab, IgG, CSF 77953-8
WNMC West Nile Virus Ab, IgM, CSF 29569-1
WNVCI West Nile CSF Interpretation 69048-7

NY State Approved

Yes

Secondary ID

36772

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.