Cautions

Serum biotin concentrations up to 1200 ng/mL do not interfere with this assay. Concentrations up to 1200 ng/mL may be present in specimens collected from patients taking extremely high doses of biotin up to 300 mg per day. In a study among 54 healthy volunteers, supplementation with 20 mg/day biotin resulted in a maximum serum biotin concentration of 355 ng/mL 1-hour post-dose.

The following drugs may interfere with this test: Cetrotide (cetrorelix), Ovitrelle, Endometrin (progesterone), and follistatin. Do not use this test to analyze specimens from patients who have received 1 or more of these products within 1 to 2 weeks of testing.

There is not a high-dose hook effect at anti-Mullerian hormone (AMH) concentrations up to 1400 ng/mL.

In rare cases, some individuals can develop antibodies to mouse or other animal antibodies (often referred to as human anti-mouse antibodies [HAMA] or heterophile antibodies), which may cause interference in some immunoassays. The presence of antibodies to streptavidin or ruthenium can rarely occur and may interfere in this assay. Caution should be used in interpretation of results, and the laboratory should be alerted if the result does not correlate with the clinical presentation.

For diagnostic purposes, the results should always be assessed in conjunction with the patient's medical history, clinical examination, and other findings.

AMH immunoassays are not standardized, and values obtained with different assay methods or kits may be different and cannot be used interchangeably.

If using as a tumor marker, test results cannot be interpreted as absolute evidence for the presence or absence of malignant disease.