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HelpTest Code LAB1060 Osteocalcin, Serum
Reporting Name
Osteocalcin, SUseful For
Monitoring and assessing effectiveness of antiresorptive therapy in patients treated for osteopenia, osteoporosis, Paget disease, or other disorders in which osteocalcin levels are elevated
As an adjunct in the diagnosis of medical conditions associated with increased bone turnover, including Paget disease, cancer accompanied by bone metastases, primary hyperparathyroidism, and renal osteodystrophy
This test is not useful for the diagnosis of osteoporosis.
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumSpecimen Required
Patient Preparation:
1. Fasting: 12 hours, required
2. For 12 hours before specimen collection, do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial.
Specimen Minimum Volume
0.75 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 14 days |
| Frozen | 90 days | |
| Ambient | 72 hours |
Reference Values
Males
<5 years: 19-75 ng/mL
5-9 years: 21-108 ng/mL
10-15 years: 19-159 ng/mL
16-17 years: 12-114 ng/mL
≥18 years: 9-42 ng/mL
Females
<5 years: 14-126 ng/mL
5-9 years: 16-152 ng/mL
10-15 years: 15-151 ng/mL
16-17 years: 9-70 ng/mL
≥18 years: 9-42 ng/mL
Day(s) Performed
Monday through Saturday
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
83937
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| OSCAL | Osteocalcin, S | 2697-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| OSCAL | Osteocalcin, S | 2697-1 |
Cautions
Measurements of bone turnover markers are not useful for the diagnosis of osteoporosis, which should be made on the basis of bone density or clinical history of low-trauma fracture.
Osteocalcin is cleared by the kidneys; therefore, elevations may be observed in patients with impaired kidney function without increased bone turnover.
Serum osteocalcin may not reflect bone formation in patients treated with the hormone 1,25-dihydroxy vitamin D or those with abnormalities in that hormone since osteocalcin is regulated by 1,25-dihydroxy vitamin D.
In rare cases, some individuals can develop antibodies to mouse or other animal antibodies (often referred to as human anti-mouse antibodies [HAMA] or heterophile antibodies), which may cause interference in some immunoassays. The presence of antibodies to streptavidin or ruthenium can also rarely occur and may also interfere in this assay. Caution should be used in interpretation of results, and the laboratory should be alerted if the result does not correlate with the clinical presentation.
In rare cases, interference due to extremely high titers of antibodies to ruthenium or streptavidin can occur.
Report Available
1 to 3 daysReject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
NY State Approved
YesMethod Name
Electrochemiluminescence Immunoassay (ECLIA)