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Test Code HCQ Hydroxychloroquine, Serum

Important Note

Order GO23910 Generic Orderable/Misc Test

Useful For

Monitoring serum hydroxychloroquine concentrations, assessing compliance, and adjusting dosage in patients

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Hydroxychloroquine, S

Specimen Type

Serum Red


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (gel tubes/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Collect specimen immediately before next scheduled dose.

2. Within 2 hours of collection, centrifuge, and aliquot serum into a plastic vial.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  21 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

For suppressive treatment of malaria, suggested plasma or serum concentrations should be >10 ng/mL.

 

For systemic lupus erythematosus, proposed serum target concentrations should be ≥500 ng/mL.

Cautions

Specimens that are obtained from serum gel tubes are not acceptable, as the drug can absorb on the gel and lead to falsely decreased concentrations.

 

Hydroxychloroquine is currently under investigational use for the prevention or postexposure prophylaxis and treatment of COVID-19; the safety and efficacy of its use have not been established.

Report Available

3 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80220

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HCQ Hydroxychloroquine, S 3684-8

 

Result ID Test Result Name Result LOINC Value
64947 Hydroxychloroquine, S 3684-8

NY State Approved

Yes

Day(s) Performed

Monday, Wednesday, Friday

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.

Secondary ID

64947