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HelpTest Code AB2GP Beta-2 Glycoprotein 1 Antibodies, IgA, Serum
Reporting Name
Beta 2 GP1 Ab IgA, SUseful For
Evaluating patients with suspected antiphospholipid syndrome by identification of beta-2 glycoprotein 1 IgA antibodies
Evaluating patients at-risk for antiphospholipid syndrome (APS) who are negative for criteria APS tests
Estimating the risk of thrombosis and/or pregnancy-related morbidity in patients with systemic lupus erythematosus
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumSpecimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 21 days |
| Frozen | 21 days |
Reference Values
<15.0 SAU (negative)
15.0-39.9 SAU (weakly positive)
40.0-79.9 SAU (positive)
≥80.0 SAU (strongly positive)
Results are reported in standard IgA anti-beta 2 glycoprotein 1 units (SAU).
Reference values apply to all ages.
Day(s) Performed
Monday, Wednesday, Friday
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86146
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| AB2GP | Beta 2 GP1 Ab IgA, S | 44447-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| AB2GP | Beta 2 GP1 Ab IgA, S | 44447-1 |
Cautions
Immunoassays for the detection of antiphospholipid antibodies, including beta-2 glycoprotein 1 (B2GPI) may not completely distinguish between autoantibodies specific for antiphospholipid syndrome and those antibodies produced in response to infectious agents with or without thrombosis. Since these antibodies may be transiently produced, documentation of persistence as outlined in the 2006 revised Sapporo guidance for the criteria antibodies would constitute best practice, see Clinical Information.
Comparative studies and interlaboratory proficiency surveys indicate that results of phospholipid antibody tests can be highly variable, and results obtained with different commercial immunoassays may yield different results.(7,8,11)
Report Available
4 to 6 daysReject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | OK |
| Heat-treated specimen | Reject |
NY State Approved
YesMethod Name
Enzyme-Linked Immunosorbent Assay (ELISA)